MANHATTAN, Kan. — Travis Releford scored 12 points and No. 3 Kansas held off No. 11 Kansas State down the stretch for a 59-55 victory Tuesday night that gave the Jayhawks sole possession of first place in the Big 12.

Ben McLemore and Jeff Withey added 11 points each for the Jayhawks (17-1, 5-0 Big 12), who pushed their nation-leading winning streak to 16 games and ended the Wildcats’ 12-game home winning streak.

Shane Southwell, who scored a career-high 19 points, got Kansas State (15-3, 4-1) within 56-53 with a scooping layup with 38.2 seconds left. Naadir Tharpe made two foul shots to restore a five-point lead.

Rodney McGruder finished with 13 points and Angel Rodriguez had 12, all in the first half, as the Wildcats lost for the 45th time in 48 games against their bitter in-state rival.

PHILADELPHIA — Achraf Yacoubou hit the tiebreaking 3-pointer late in the second half to help Villanova to the upset.

The Wildcats (12-7, 3-3 Big East) led by as many as 10 points in the first half and rallied late in the second to send the Cardinals (16-3, 4-2) to their second straight loss.

Ryan Arcidiacono scored 15 points, and JayVaughn Pinkston and Mouphtaou Yarou each scored 11 for Villanova. Peyton Siva had 15 points and 13 assists for the Cardinals and Wayne Blackshear scored 17 points.

MADISON, Wis. — Keith Appling scored 19 points and Branden Dawson added 18 for Michigan State (17-3, 6-1 Big Ten).

Mike Bruesewitz led Wisconsin (13-6, 4-2) with 10 points.

COLUMBUS, Ohio — Deshaun Thomas, who missed part of the second half with a cut above his eye, scored 16 points as Ohio State (14-4, 4-2 Big Ten) built a big lead and then held on.

WINSTON-SALEM, N.C. — Freshman Devin Thomas had a season-high 25 points, 14 rebounds and four blocks for Wake Forest.

Travis McKie added 16 points for the Demon Deacons (10-8, 3-3 Atlantic Coast Conference), including two free throws with 3.4 seconds left that helped Wake Forest hold on down the stretch in a wild final 4½ minutes.

N.C. State (15-4, 4-2) led by 16 points in the first half and 12 at halftime only to see the Demon Deacons rally and push ahead to their own 10-point lead. Rodney Purvis scored 18 points to lead the Wolfpack.